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Peptide record

TPDB61392

Tat-C (48–57) Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB61392
Tat-C (48–57)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: DEACM photo-cleavable group and 4’-(aminomethyl) fluorescein labelled nanoparticles (NP) N-terminal: Acetylation
Sequence
Ac-CGGFRKKRRQRRR
Physicochemical Analysis
C69H126N34O15S1
ANDEHILMPSTWYV
R
1704.04
12.71
8
0
1
+8
6.07
-2.600
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
2
G
0
H
0
I
0
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C69H126N34O15S1
1704.04
12.71
+8
6.07
-2.600
Free
DEACM photo-cleavable group and 4’-(aminomethyl) fluorescein labelled nanoparticles (NP)
L
Cationic
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs Cells

Assay & Model

C57BL/6 mouse model of CNV28
C57BL/6 mouse model of CNV28

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
Doxorubicin
HUVECs incubated with NP-AMF-CPPs exhibited 9.9-fold greater fluorescence than those exposed to peptide-free nanoparticles
In vitro and in vivo