Back to search

Peptide record

TPDB61390

Pep-1 Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61390
Pep-1
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0 TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from BBPpredict, CPPsite3.0, and TumorHoPe2.0, with an available 3D structural model.
Sequence
CGEMGWVRC
Physicochemical Analysis
C42H65N13O12S3
ANDQHILKFPSTY
CG
1040.24
6.14
1
1
3
-0
0.36
0.156
32.22
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5625
540.74
2
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
1
E
0
Q
2
G
0
H
0
I
0
L
0
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
9
C42H65N13O12S3
1040.24
6.14
-0
0.36
0.156
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Glioblastoma multiforme (GBM)
IL-13Ra2

Source & Reference

TumorHoPe2.0
TumorHoPe2
An interleukin 13 receptor α 2-specific peptide homes to human Glioblastoma multiforme xenografts
2012
Hetal Pandya et al. Neuro Oncol. 2012 Jan 14(1):6-18.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U-251 MG, T98G, SnB19 GBM cells, G-26 cells (murine glioma cell line), SnB19 GBM cells, G48a cells
5–6-week-old female athymic nudemice
phage display library
Ph.D-C7C phages display library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2017
Padmanaban Guruprasath et al. Biomaterials. 2017 Oct:142:101-111.

Other

IL4R
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Homing
Human Glioblastoma
Interleukin 13 receptor 2 (IL-13R 2)

Source & Reference

TumorHoPe2.0
TumorHoPe2
PEGylated Polyamidoamine dendrimer conjugated with tumor homing peptide as a potential targeted delivery system for glioma
2016
Jiang Y et al. Colloids Surf B Biointerfaces. 2016 Nov 1:147:242-249

Other

U87MG cells (Human malignant glioblastoma cells), BCEC cells (rat’s brain capillary endothelial cell line)
4-5 weeks old BALB/c nude male mice
Synthetic
PEGylated Polyamidoamine (PAMAM), FITC, Cy5.5
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Brain tumor
IL-13Ra2

Source & Reference

TumorHoPe2.0
TumorHoPe2
Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via interleukin 13 receptor α2-mediated endocytosis
2014
Wang B et al. Biomaterials.2014 Jul 35(22):5897-907

Other

C6 cell line
4-5 weeks old male mice
Synthetic
PEG-PLGA
Additional Detail Fields 4 fields
IL4R PEGylated Polyamidoamine (PAMAM), FITC, Cy5.5 PEG-PLGA
U-251 MG, T98G, SnB19 GBM cells, G-26 cells (murine glioma cell line), SnB19 GBM cells, G48a cells U87MG cells (Human malignant glioblastoma cells), BCEC cells (rat’s brain capillary endothelial cell line) C6 cell line
5–6-week-old female athymic nudemice 4-5 weeks old BALB/c nude male mice 4-5 weeks old male mice
Ph.D-C7C phages display library