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Peptide record

TPDB61388

HIV-gp41 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB61388
HIV-gp41
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: CAAKA spacer N-terminal: Addition of Cysteine
Sequence
CGALFLGWLGAAGSTMGA
Physicochemical Analysis
C75H115N19O21S2
RNDEQHIKPYV
G
1682.97
5.33
0
0
10
-0
-5.49
1.189
87.22
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
326.80
3
Residue Composition
number
4
A
0
R
0
N
0
D
1
C
0
E
0
Q
5
G
0
H
0
I
3
L
0
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 3 K: 0 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C75H115N19O21S2
1682.97
5.33
-0
-5.49
1.189
Free
CAAKA spacer
L
Linear
Addition of Cysteine
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Drug Resistant Melanoma (A375 And A375-R), Mesothelioma (Msto And Msto-R), And Glioma (Rat 9L And 9L-R, And Human U87 And Ln18) Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Photoluminescent multi-shelled quantum dot (QD)
Cytoplasm and Endosomes
Cell specific internalization
In vitro
CCHHHHHHHTTSCHHHHTTTTTTSCC
Additional Detail Fields 1 fields
CCHHHHHHHTTSCHHHHTTTTTTSCC