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Peptide record

TPDB61386

Compound 17 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61386
Compound 17
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
CFWRRRRCFWRRRRC-NH2
Physicochemical Analysis
C97H151N41O16S3
ANDEQGHILKMPSTYV
R
2243.71
12.40
8
0
4
+8
-0.20
-1.647
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11125
495.83
3
Residue Composition
number
0
A
8
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C97H151N41O16S3
2243.71
12.40
+8
-0.20
-1.647
Amidation
L
Cationic
Bicyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mda, HeLa, A549 Cells And Ht-29 Human Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Bicyclic L Cationic
Synthetic
RhB (rhodamine B with piperazine linker) at N terminus
12.2 microMolar uptake in HeLa cells relative to TAT 1 μM
In vitro