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Peptide record

TPDB61380

cyclic L-Ac-C(FKFE)2CG-NH2 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB61380
cyclic L-Ac-C(FKFE)2CG-NH2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-CFKFEFKFECG-NH2
Physicochemical Analysis
C66H89N13O16S2
ARNDQHILMPSTWYV
F
1384.63
6.29
2
2
4
-0
1.03
0.091
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
9.03
2
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
2
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
4
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C66H89N13O16S2
1384.63
6.29
-0
1.03
0.091
Amidation
L
Amphipathic
Cyclic
Acetylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549, H441

Assay & Model

C57B6 mice
C57B6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Amphipathic
Synthetic
Rh-siRNA , TTF-1 siRNA
Cytoplasm
Show modest degree of translocation
In vitro and in vivo
CCCCSSCSCCGGGCC
Additional Detail Fields 1 fields
CCCCSSCSCCGGGCC