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Peptide record

TPDB61375

Alexa488-Melan-A-TAT Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61375
Alexa488-Melan-A-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugation with Alexa488 C5 maleimide
Sequence
CELAGIGILTVRKKRRQRRR
Physicochemical Analysis
C101H189N41O25S1
NDHMFPSWY
R
2409.93
12.41
8
1
6
+7
7.52
-0.910
97.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
6
R
0
N
0
D
1
C
1
E
1
Q
2
G
0
H
2
I
2
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 1 E: 1 Q: 1 G: 2 H: 0 I: 2 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C101H189N41O25S1
2409.93
12.41
+7
7.52
-0.910
Free
L
Cationic
Linear
Conjugation with Alexa488 C5 maleimide
N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

DCs, HUVECs and Jurkat cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
Fluorophore (Alexa488) and Protein (ovalbumin)
Lysosome
Higher uptake efficiency
Clathrin mediated endocytosis
In vitro
CCSSSCSTTCSGGGGGCCCC
Additional Detail Fields 1 fields
CCSSSCSTTCSGGGGGCCCC