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Peptide record

TPDB61373

RLT Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB61373
RLT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Gold nanorods (AuNRs)
Sequence
CEKLKEAFRLTRKRGLKLA
Physicochemical Analysis
C100H178N32O25S1
NDQHIMPSWYV
LK
2260.77
10.95
7
2
7
+5
6.63
-0.689
92.63
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
3
R
0
N
0
D
1
C
2
E
0
Q
1
G
0
H
0
I
4
L
4
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C100H178N32O25S1
2260.77
10.95
+5
6.63
-0.689
Free
Gold nanorods (AuNRs)
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sgc-7901 Cells.

Assay & Model

BALB/c-nu male nude mice
BALB/c-nu male nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
FITC-labeled
Nucleus
SGC-7901 had a cellular uptake rate for RLT-AuNRs of 85.3%, 96.4%, and 99.3% at 1 h, 4 h, and 24 h, respectively. The uptake rates for AuNRs were significantly lower: 53.5%, 75.6%, and 84.8% at 1 h, 4 h, and 24 h, respectively
In vitro and in vivo