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Peptide record

TPDB61369

HSV1-VP22 Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB61369
HSV1-VP22
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 35-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: CAAKA spacer N-terminal: Addition of Cysteine
Sequence
CDAATATRGRSAASRPTERPRAPARSASRPRRPVD
Physicochemical Analysis
C150H260N62O49S1
NQHILKMFWY
R
3748.16
12.30
9
3
9
+6
13.44
-1.246
31.14
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
8
Residue Composition
number
8
A
9
R
0
N
2
D
1
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
5
P
4
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 8 R: 9 N: 0 D: 2 C: 1 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 5 S: 4 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
35
C150H260N62O49S1
3748.16
12.30
+6
13.44
-1.246
Free
CAAKA spacer
L
Linear
Addition of Cysteine
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Drug Resistant Melanoma (A375 And A375-R), Mesothelioma (Msto And Msto-R), And Glioma (Rat 9L And 9L-R, And Human U87 And Ln18) Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Photoluminescent multi-shelled quantum dot (QD)
Cytoplasm and Endosomes
Cell specific internalization
In vitro
CHHHHCSTHHHHGGGGTTTTTC
Additional Detail Fields 1 fields
CHHHHCSTHHHHGGGGTTTTTC