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Peptide record

TPDB61364

iRGD Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61364
iRGD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Acetylation
Sequence
Ac-CCRGDKGPDC
Physicochemical Analysis
C38H64N14O15S3
ANEQHILMFSTWYV
C
1053.19
6.01
2
2
0
-0
4.01
-1.030
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
11.87
3
Residue Composition
number
0
A
1
R
0
N
2
D
3
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 3 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C38H64N14O15S3
1053.19
6.01
-0
4.01
-1.030
Free
L
Linear
Acetylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs And Hce Cell Line

Assay & Model

Brown Norway (BN) male rats
Brown Norway (BN) male rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
(PLGA) nanoparticles (NPs) labelled with Nile red
Nucleus
The red fluorescence intensity of the NPs at 6 h followed the order of iRGD–TAT-Nile red NP > TAT-Nile red-NP and iRGD-Nile red NP > mPEG–PLGA-Nile red-NP.
In vitro and in vivo
CCSSCCSSCC
Additional Detail Fields 1 fields
CCSSCCSSCC