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Peptide record

TPDB61363

cNGR Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB61363
cNGR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 6-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CCNGRC
Physicochemical Analysis
C21H38N10O8S3
ADEQHILKMFPSTWYV
C
654.77
8.02
1
0
0
+1
0.52
-0.150
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
19.09
4
Residue Composition
number
0
A
1
R
1
N
0
D
3
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 3 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C21H38N10O8S3
654.77
8.02
+1
0.52
-0.150
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht1080 (Human Fibrosarcoma) Cells

Assay & Model

Female BALB/c nude mice weighing 22–24 g
Female BALB/c nude mice weighing 22–24 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Dox-loaded nanoliposomes
Mitochondria, Endoplasmic Reticulum and Golgi Apparatus
cNGR-tiR9 Lip-Dox was about 1.3-fold higher than that of cNGR-Lip- Dox,
In vitro and in vivo
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC