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Peptide record

TPDB61352

K-FGF Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB61352
K-FGF
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: CAAKA spacer N-terminal: Addition of Cysteine
Sequence
CAAVALLPAVLLAHLLAP
Physicochemical Analysis
C83H142N20O19S1
RNDEQGIKMFSTWY
AL
1756.22
7.15
1
0
14
+0
-2.62
2.117
195.56
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
6
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
1
H
0
I
6
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 6 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
18
C83H142N20O19S1
1756.22
7.15
+0
-2.62
2.117
Free
CAAKA spacer
L
Linear
Addition of Cysteine
N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Drug Resistant Melanoma (A375 And A375-R), Mesothelioma (Msto And Msto-R), And Glioma (Rat 9L And 9L-R, And Human U87 And Ln18) Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Photoluminescent multi-shelled quantum dot (QD)
Cytoplasm and Endosomes
Cell specific internalization
In vitro
CCCCSGGGSSCC
Additional Detail Fields 1 fields
CCCCSGGGSSCC