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Peptide record

TPDB61301

P4 (SmacN7–Arg8) Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB61301
P4 (SmacN7–Arg8)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: SmacN7
Sequence
AVPIAQKKRRRRRRRRE-NH2
Physicochemical Analysis
C92H174N44O21
NDCGHLMFSTWY
R
2232.68
12.88
10
1
4
+9
10.93
-2.359
51.76
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
8
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 8 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C92H174N44O21
2232.68
12.88
+9
10.93
-2.359
Amidation
SmacN7
L
Cyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U266 Mm Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Cyclic L
Chimeric
FITC at N terminal via Ahx linker
P4, expected enhancement of uptake was not observed.
In vitro