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Peptide record

TPDB61292

L-R5 Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB61292
L-R5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 5-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Myrsitoylation
Sequence
ARRWR
Physicochemical Analysis
C32H53N15O6
NDCEQGHILKMFPSTYV
R
743.87
12.70
3
0
2
+3
0.41
-2.520
20.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
739.38
0
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
5
C32H53N15O6
743.87
12.70
+3
0.41
-2.520
Free
L
Linear
Myrsitoylation
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Human Nasal Epithelial Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
4-kDa dextran and BCS class III drug naloxone.
L-R5 increased the permeability of FD-4 across nasal human primary epithelial cells by about 10 times over a time course of 150 minutes.
In vitro
CHHHHHHHHHHHHHHHHSCC
Additional Detail Fields 1 fields
CHHHHHHHHHHHHHHHHSCC