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Peptide record

TPDB61288

kEA2x4 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB61288
kEA2x4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Extended with Alanine and an 6-aminohexanoic acid (Ahx) spacer
Sequence
ARRRRCSDRFRNCPADEALCGRRRR-NH2
Physicochemical Analysis
C120H210N56O34S3
QHIKMTWYV
R
3077.52
12.03
10
3
5
+7
10.67
-1.692
27.60
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
4.06
5
Residue Composition
number
3
A
10
R
1
N
2
D
3
C
1
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 10 N: 1 D: 2 C: 3 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C120H210N56O34S3
3077.52
12.03
+7
10.67
-1.692
Amidation
L
Arginine rich
Cyclic
Extended with Alanine and an 6-aminohexanoic acid (Ahx) spacer
N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Arginine rich
Synthetic
Fluorophore (FITC)
Vesicles
Endocytic pathway
In vitro
CCCCCSTTTTSCSCCCSSSCSSCCC
Additional Detail Fields 1 fields
CCCCCSTTTTSCSCCCSSSCSSCCC