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Peptide record

TPDB61277

CpMTP Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB61277
CpMTP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nanoparticle
Sequence
ARLLWLLRGLTLGTAPRRA-NH2
Physicochemical Analysis
C97H168N32O22
NDCEQHIKMFSYV
L
2134.60
12.88
4
0
10
+4
-1.73
0.289
138.95
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
257.66
2
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
6
L
0
K
0
M
0
F
1
P
0
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 6 K: 0 M: 0 F: 0 P: 1 S: 0 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
19
C97H168N32O22
2134.60
12.88
+4
-1.73
0.289
Amidation
Nanoparticle
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Fibroblast Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC-labeled pDNA (pCAG-GFP-ND)
Mitochondria
Transfection mediated by MTS-WRAP5/pND1 systems showed less fluorescence comparison to MTS-(KH)9 and CpMTP peptides
In vitro
CCCCCCSCC
Additional Detail Fields 1 fields
CCCCCCSCC