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Peptide record

TPDB61276

motif I Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB61276
motif I
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
ARLAKTRKVVRLIKFLLKATA
Physicochemical Analysis
C111H202N34O24
NDCEQGHMPSWY
ALK
2397.04
12.72
7
0
12
+7
2.45
0.362
139.52
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
4
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
4
K
0
M
1
F
0
P
0
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C111H202N34O24
2397.04
12.72
+7
2.45
0.362
Free
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
FAM
Cytosol
The motif I peptide has delivered its FAM cargo uniformly to the majority of the cells.
In vitro
CTHHHHHHHTHHHHHHHSCC
Additional Detail Fields 1 fields
CTHHHHHHHTHHHHHHHSCC