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Peptide record

TPDB61265

Ala43 substitution mutant of pAntp (43-58) Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61265
Ala43 substitution mutant of pAntp (43-58)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation (Labeled with Biotinyl-beta-Alanine)
Sequence
AQIKIWFQNRRMKWKK-NH2
Physicochemical Analysis
C101H161N31O20S1
DCEGHLPSTYV
K
2161.65
12.44
6
0
7
+6
1.31
-1.337
55.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
508.87
3
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C101H161N31O20S1
2161.65
12.44
+6
1.31
-1.337
Amidation
L
Amphipathic
Linear
Biotinylation (Labeled with Biotinyl-beta-Alanine)
N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HaCat/ A549 cells

Source & Reference

CPPsite3.0
CPPsite3
US 7153931

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Biotin
Probably Cytosol and nucleus, nucleoi
High (90% relative to (pAntp) (43-58))
Non-endocytic mechanism
In vitro
CCCCCCCCCCCTTTTC
Additional Detail Fields 1 fields
CCCCCCCCCCCTTTTC