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Peptide record

TPDB61244

S4(13)-PV Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61244
S4(13)-PV
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with rhodamine B
Sequence
ALWKTLLKKVLKAPKKKRKV-NH2
Physicochemical Analysis
C114H206N32O22
NDCEQGHIMFSY
K
2377.09
11.97
9
0
9
+9
5.03
-0.585
117.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
231.38
1
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
8
K
0
M
0
F
1
P
0
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 8 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
20
C114H206N32O22
2377.09
11.97
+9
5.03
-0.585
Amidation
L
Karyophilic
Linear
Conjugation with rhodamine B
N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3
US 20040132970

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Karyophilic
Chimeric
Fluorophore (rhodamine)
Cytoplasm and nucleus
Non-endocytic mechanism
In vitro
CTHHHHHHHHTTSCSSSCCC
Additional Detail Fields 1 fields
CTHHHHHHHHTTSCSSSCCC