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Peptide record

TPDB61238

MPG Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB61238
MPG
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
ALFLGFLGAAGSTMGAWSQPKKKRKV
Physicochemical Analysis
C127H205N35O31S1
NDCEHIY
AGK
2750.30
11.80
5
0
12
+5
-0.39
0.012
71.54
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
199.98
4
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
0
I
3
L
4
K
1
M
2
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 3 K: 4 M: 1 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C127H205N35O31S1
2750.30
11.80
+5
-0.39
0.012
Free
Nanoparticles
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
pEGFP-N1-nef-vif-gp160-p24
MPG could deliver effectively pEGFP-nef-vif-gp160-p24 (38.38%,)
In vitro
CCCCCCCCSSCSCCCTTCSTTHIIIIITTSHHHHTTTSTTTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
pEGFP-N1-nef-vpu-gp160-p24
MPG could deliver effectively pEGFP-nef-vpu-gp160-p24(25.36%).
In vitro
CCHHHHGGGCC
Additional Detail Fields 1 fields
CCCCCCCCSSCSCCCTTCSTTHIIIIITTSHHHHTTTSTTTC CCHHHHGGGCC