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Peptide record

TPDB61199

buCATHL4I(4I) Cell-penetrating Peptides Tumor-homing Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB61199
buCATHL4I(4I)
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 14-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
AIPWILIWRLLFKG
Physicochemical Analysis
C89H136N20O15
NDCEQHMSTYV
IL
1726.18
11.49
2
0
10
+2
-5.35
1.236
174.29
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
637.24
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
3
L
1
K
0
M
1
F
1
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C89H136N20O15
1726.18
11.49
+2
-5.35
1.236
Free
L
Linear
Free
N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
EGFP protein
Cytoplasm
EGFP‐CAT 2‐8‐times higher intensity than other derivative and 3‐6 times higher than EGFP‐LL37, EGFP‐IL, EGFP‐L‐K6, and EGFP‐TAT
In vitro
CCCCCHHHHTTCCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Liver cancer, Cervical cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Screening and characterization of a novel high-efficiency tumor-homing cell-penetrating peptide from the buffalo cathelicidin family
2019
Xu Y Y et al. J Pept Sci. 2019 Sep 25(9):e3201

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human Cervical Tumor cell line HeLa, Human Hepatoma cell line SMMC‐7721, Human Non‐Small‐Cell Lung Tumor cell line A549, carcinoma cell line NCI‐H460, Human Embryonic Lung cell line MRC‐5
Synthetic
Additional Detail Fields 2 fields
CCCCCHHHHTTCCC
Human Cervical Tumor cell line HeLa, Human Hepatoma cell line SMMC‐7721, Human Non‐Small‐Cell Lung Tumor cell line A549, carcinoma cell line NCI‐H460, Human Embryonic Lung cell line MRC‐5