Back to search

Peptide record

TPDB61160

PF14-E Cell-penetrating Peptides modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61160
PF14-E
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 21-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nanoparticles N-terminal: Stearylation
Sequence
AGYLLGKLLEOLAAAALOOLL-NH2
Physicochemical Analysis
C87H149N19O22
RNDCQHIMFPSTWV
L
1813.25
6.87
1
1
14
-0
-3.24
1.424
172.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
82.17
1
Residue Composition
number
5
A
0
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
8
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 8 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C87H149N19O22
1813.25
6.87
-0
-3.24
1.424
Amidation
Nanoparticles
Modified
Linear
Stearylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Male and female BALB/c mice (8-week-old)
Male and female BALB/c mice (8-week-old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
pDNA (pGL3) and p-CMV-Luc2(pLuc)
The lowest efficacy was observed with PF14-E, a CPP with the net charge of +3.
In vitro and in vivo