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Peptide record

TPDB61154

TK peptide Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61154
TK peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
AGYLLGKINLKKLAKLLLIL-NH2
Physicochemical Analysis
C107H191N25O23
RDCEQHMFPSTWV
L
2195.85
10.64
4
0
13
+4
-1.98
1.090
205.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
67.86
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
8
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 8 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C107H191N25O23
2195.85
10.64
+4
-1.98
1.090
Amidation
L
Cationic
Linear
Free
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C26 cells and HepG2 cells

Assay & Model

BALB/C mice
BALB/C mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nanoparticle (Liposomes)
Cytosol, ER and Golgi body
High
Electrostatic attraction and clathrin-mediated endocytosis
In vitro and in vivo
CTTCTTSCCHHHHHHHHSCC
Additional Detail Fields 1 fields
CTTCTTSCCHHHHHHHHSCC