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Peptide record

TPDB61153

Transportan-PKI Cell-penetrating Peptides standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB61153
Transportan-PKI
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 38-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
AGYLLGKINLKALAALAKKILTYADFIASGRTGRRNAI
Physicochemical Analysis
C184H311N53O48
CEQHMPWV
A
4033.82
11.04
7
1
21
+6
-0.06
0.316
123.68
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
73.88
7
Residue Composition
number
8
A
3
R
2
N
1
D
0
C
0
E
0
Q
4
G
0
H
4
I
6
L
4
K
0
M
1
F
0
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 8 R: 3 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 4 L: 6 K: 4 M: 0 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
38
C184H311N53O48
4033.82
11.04
+6
-0.06
0.316
Free
L
Linear
Conjugation with rhodamine B
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO K1, HeLa, A549 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Fluorophore (rhodamine)
Equal to Polyarginine-PKI and less than pAntp-PKI,
In vitro
CCCCCCCCCHHHHHHHHHHHHHHHHHHTCCCSSCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCHHHHHHHHHHHHHHHHHHTCCCSSCCCCC