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Peptide record

TPDB61148

TH peptide Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61148
TH peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
AGYLLGHINLHHLAHLHHIL-NH2
Physicochemical Analysis
C107H163N33O23
RDCEQKMFPSTWV
HL
2279.68
8.16
6
0
11
+1
0.94
0.530
166.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
65.36
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
6
H
2
I
6
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 6 I: 2 L: 6 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C107H163N33O23
2279.68
8.16
+1
0.94
0.530
Amidation
L
Cationic
Linear
Free
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C26 cells and HepG2 cells

Assay & Model

BALB/C mice
BALB/C mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nanoparticle (Liposomes)
Cytosol, ER and Golgi body
High
Electrostatic attraction and clathrin-mediated endocytosis
In vitro and in vivo
CCCCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCCC