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Peptide record

TPDB61141

PepH3 Blood-Brain Barrier Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB61141
PepH3
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 7-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
AGILKRW
Physicochemical Analysis
C40H66N12O8
NDCEQHMFPSTYV
ARGILKW
843.04
11.49
2
0
4
+2
-1.08
0.057
125.71
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
652.40
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
7
C40H66N12O8
843.04
11.49
+2
-1.08
0.057
Free
L
Linear
Hydrophobic
Linear
Free
Similarity
Cationic
AlaGlyIleLeuLysArgTrp
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

5 microCi/ml
Gamma counter radioactivity measure for TcPz
67.33+/- 1.20
Origin/Source

Source & Reference

NA
B3Pdb

Other

Derived from dengue virus capsid
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
Evidence 2 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

5 microCi/ml
Gamma counter radioactivity measure for gaNODA
72.63 +/- 0.70
Origin/Source

Source & Reference

NA
B3Pdb

Other

Derived from dengue virus capsid
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
Evidence 3 Activity

Activity

Blood-Brain Barrier
67.23%

Assay & Model

Initial concentration in donor chamber-Culture
Origin/Source
Translocated

Source & Reference

NA
B3Pdb

Other

viral
Permeability
99mTc(CO)3+
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.03 %/g

Assay & Model

Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

viral
Intravenous
Permeability
99mTc(CO)3+
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3 Cell

Assay & Model

CD1 mice
CD1 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Protein derived
Radiolabelled using fac-[99mTc(CO)3(H2O)3]+ and 67-Ga-labeled
BEB translocation of PepH3 was high (67.2±1.2 % at 24 h) and the radioactivity associated to the cell (membrane and internalized peptide) was low
In vitro and in vivo
CCSHHHHHHHHHHC
Additional Detail Fields 2 fields
CCSHHHHHHHHHHC
Intravenous