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Peptide record

TPDB61136

pHLIP Cell-penetrating Peptides Tumor-homing Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB61136
pHLIP
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 37-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Chemical: FITC-labeled
Sequence
AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG
Physicochemical Analysis
C193H288N44O57S1
HKMS
L
4168.73
3.32
1
6
20
-5
-0.41
0.281
116.22
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
13980
335.35
8
Residue Composition
number
5
A
1
R
1
N
4
D
1
C
2
E
1
Q
2
G
0
H
1
I
8
L
0
K
0
M
1
F
2
P
0
S
3
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 4 C: 1 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 8 K: 0 M: 0 F: 1 P: 2 S: 0 T: 3 W: 2 Y: 2 V: 1
Chemical Descriptors
37
C193H288N44O57S1
4168.73
3.32
-5
-0.41
0.281
Free
FITC-labeled
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MCF-7/Adr Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Doxorubicin (DOX) , Liposome
Cytoplasm and nucleus
At pH 7.4, the uptake of Py-SS-DOX, DOX-SH and pHLIP-SS-DOX was all lower than that of DOX. However, at pH 6.0, the uptake of Py-SS-DOX, DOX-SH and pHLIP-SS-DOX was all higher than that of DOX for both cell lines.
In vitro
CCCCCCCHHHHHHHHHHHHCC
Additional Detail Fields 1 fields
CCCCCCCHHHHHHHHHHHHCC