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Peptide record

TPDB61134

pHlip Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB61134
pHlip
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
AEEQQPWAQYLELLFPTETLLLEWG
Physicochemical Analysis
C142H206N30O42
RNDCHIKMSV
L
3005.37
2.90
0
5
12
-5
3.56
-0.276
101.60
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
415.59
6
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
5
E
3
Q
1
G
0
H
0
I
6
L
0
K
0
M
1
F
2
P
0
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 5 Q: 3 G: 1 H: 0 I: 0 L: 6 K: 0 M: 0 F: 1 P: 2 S: 0 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
25
C142H206N30O42
3005.37
2.90
-5
3.56
-0.276
Free
L
Amphiphilic
Linear
Free
NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Protein derived
GFP-HiBiT fusion protein
Cytosol
Not significantly higher than GFP alone
Endocytosis
In vitro
CCSTTTCCCCSCSCCC
Additional Detail Fields 1 fields
CCSTTTCCCCSCSCCC