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Peptide record

TPDB61131

NOP53397-410 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB61131
NOP53397-410
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
AEADKPRRLGRLK-NH2
Physicochemical Analysis
C64H116N24O18
NCQHIMFSTWYV
R
1509.78
11.37
5
2
4
+3
6.66
-1.469
75.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
2
A
3
R
0
N
1
D
0
C
1
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C64H116N24O18
1509.78
11.37
+3
6.66
-1.469
Amidation
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87, PC3, And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM-conjugated
Showed fluorescent signal in more than 10% of the cells.
In vitro
CCCCCCSSCCCC
Additional Detail Fields 1 fields
CCCCCCSSCCCC