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Peptide record

TPDB61129

30Kc19α Cell-penetrating Peptides standard
88 amino acids
Basic Information
3D PDB MODEL
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TPDB61129
30Kc19α
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 88-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Hydroxyapatite binding tag (HAB) at N terminal
Sequence
ADSDVPNDILEEQLYNSVVVADYDSAVEKSKHLYEEKKSEVITNVVNKLIRNNKMNCMEYAYQLWLQGSKDIVRDCFPVEFRLIFAEN
Physicochemical Analysis
C456H710N118O144S4
V
10277.60
4.44
11
16
38
-6
27.54
-0.428
91.82
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
13075
127.22
25
Residue Composition
number
5
A
3
R
8
N
7
D
2
C
9
E
3
Q
1
G
1
H
5
I
7
L
7
K
2
M
3
F
2
P
6
S
1
T
1
W
5
Y
10
V
Amino Acid Distribution
A: 5 R: 3 N: 8 D: 7 C: 2 E: 9 Q: 3 G: 1 H: 1 I: 5 L: 7 K: 7 M: 2 F: 3 P: 2 S: 6 T: 1 W: 1 Y: 5 V: 10
Chemical Descriptors
88
C456H710N118O144S4
10277.60
4.44
-6
27.54
-0.428
Free
Hydroxyapatite binding tag (HAB) at N terminal
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC/C=C\CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C/C(=C/C)/C=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hmscs Cells

Assay & Model

Balb/c-nu female mice
Balb/c-nu female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
OG488-labelled RUNX2
Cytoplasm and nucleus
HAB-30Kc19α-RUNX2 could penetrate cells and show fluorescences in the cell cytoplasm but also in the nucleus.
In vitro and in vivo
CCCCCCEETTEECSSSCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCEETTEECSSSCCCCCCCCC