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Peptide record

TPDB61127

SCP Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB61127
SCP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Bioreducible polymer (TSP)
Sequence
ACTGSTQHQCG
Physicochemical Analysis
C40H65N15O17S2
RNDEILKMFPWYV
CQGT
1092.17
7.00
1
0
1
-0
1.90
-0.582
9.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
11.45
7
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
2
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 2 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C40H65N15O17S2
1092.17
7.00
-0
1.90
-0.582
Free
Bioreducible polymer (TSP)
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7 And Hek293T Cells

Assay & Model

Ai14D mice(6–8 weeks old)
Ai14D mice(6–8 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-labeled pCas12f pDNA , MC Cas9-Cre
Transfection efficiency of pCas12f complexed with TSPscp was as high as 80%.
In vitro and in vivo
CCCSSCCCSCCCTTSCC
Additional Detail Fields 1 fields
CCCSSCCCSCCCTTSCC