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Peptide record

TPDB61120

EA1x8 L Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB61120
EA1x8 L
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: All cysteines were capped with iodoacetamide N-terminal: Extended with Alanine and an 6-aminohexanoic acid (Ahx) spacer
Sequence
ACSGSGSGCGSGSGSCGRRRRRRRR-NH2
Physicochemical Analysis
C92H169N49O32S3
NDEQHILKMFPTWYV
R
2569.84
12.40
8
0
1
+8
6.44
-1.372
4.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
4.86
9
Residue Composition
number
1
A
8
R
0
N
0
D
3
C
0
E
0
Q
7
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
6
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 7 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 6 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C92H169N49O32S3
2569.84
12.40
+8
6.44
-1.372
Amidation
All cysteines were capped with iodoacetamide
L
Arginine rich
Cyclic
Extended with Alanine and an 6-aminohexanoic acid (Ahx) spacer
N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Arginine rich
Synthetic
Fluorophore (FITC)
Vesicles
Endocytic pathway
In vitro
CCCCCCBTTBBSCSCCGGGTCCSCC
Additional Detail Fields 1 fields
CCCCCCBTTBBSCSCCGGGTCCSCC