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Peptide record

TPDB61071

MTS–AR₈ Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB61071
MTS–AR₈
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-AAVLLPVLLAAPARRRRRRRR-NH2
Physicochemical Analysis
C107H199N45O22
NDCEQGHIKMFSTWY
R
2468.05
13.25
8
0
11
+8
4.43
-0.314
125.71
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
5
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C107H199N45O22
2468.05
13.25
+8
4.43
-0.314
Amidation
L
Amphiphilic
Linear
Acetylation
N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih/3 T3 And HeLa Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Plasmid DNA pSF-CMV-SEAP (OG105)
In HeLa cells, the positive control, the cationic polymer ChargeFECT®, showed superior transfection compared to MTS–AR8
In vitro
CCCCCTTTSCCTTSCSCSSCC
Additional Detail Fields 1 fields
CCCCCTTTSCCTTSCSCSSCC