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Peptide record

TPDB61066

CP-FUS-NLS Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB61066
CP-FUS-NLS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
AAVALLPAVLLALLAPSRGEHRQDRRERPY
Physicochemical Analysis
C148H248N48O40
NCIKMFTW
AL
3339.89
10.95
6
3
15
+2
7.17
-0.167
117.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
44.61
3
Residue Composition
number
6
A
5
R
0
N
1
D
0
C
2
E
1
Q
1
G
1
H
0
I
6
L
0
K
0
M
0
F
3
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 6 R: 5 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 1 H: 1 I: 0 L: 6 K: 0 M: 0 F: 0 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
30
C148H248N48O40
3339.89
10.95
+2
7.17
-0.167
Free
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

6- to 8-week-old male BALB/c WT mice
6- to 8-week-old male BALB/c WT mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM dye
Nucleus
CP-FUS-NSL showed green fluorescence in both tubules, and glomeruli successfully reached the kidneys.
In vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC