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Peptide record

TPDB61048

Ku-A4 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61048
Ku-A4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with CF
Sequence
AAKKAAAKKAAAKKAAAKKA
Physicochemical Analysis
C84H158N28O21
RNDCEQGHILMFPSTWYV
A
1896.35
11.36
8
0
12
+8
5.88
-0.480
60.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
12
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 12 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C84H158N28O21
1896.35
11.36
+8
5.88
-0.480
Free
L
Cationic
Linear
Conjugated with CF
N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

L929 Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
plasmid DNA pEGFP-C2 and CF dye
Cytosol and Nucleus
Ku-A4 and Ku-P4 had superior cell penetration ability compared to those of other Ku-peptides in the series.
Direct membrane translocation and Endocytosis
In vitro
CCSSCCCCCCCCCCC
Additional Detail Fields 1 fields
CCSSCCCCCCCCCCC