TPDB

3D PDB MODEL

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TPDB ID TPDB60806

Peptide_Name

Peptide YY

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 36-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRY

FASTA

>TPDB60806|Neuropeptide|length=36
YPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRY

Formula C190H287N53O58

Absent Amino Acids CIMFW

Common Amino Acids Y

Mass 4241.69

PI 7.60

Basic Residues 6

Acidic Residues 5

Hydrophobic Residues 14

Net Charge +0

Boman Index 10.29

Hydrophobicity -1.094

Aliphatic Index 62.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 7450

Absorbance 280nm 175.64

Polar Residues 11

number

4

A

4

R

1

N

1

D

0

C

4

E

1

Q

1

G

1

H

0

I

4

L

1

K

0

M

0

F

4

P

3

S

1

T

0

W

5

Y

1

V

Amino Acid Distribution

A: 4 R: 4 N: 1 D: 1 C: 0 E: 4 Q: 1 G: 1 H: 1 I: 0 L: 4 K: 1 M: 0 F: 0 P: 4 S: 3 T: 1 W: 0 Y: 5 V: 1

Length

36

Formula

C190H287N53O58

Mass

4241.69

PI

7.60

Net Charge

+0

Boman Index

10.29

Hydrophobicity

-1.094

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 5

Receptor Organisms Canis lupus familiaris Canis lupus familiaris

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family NPY

Receptor Lengths 382 446

Receptor Ligands NP07688 NP07694 NP07688 NP07694

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5 Neuropeptide Y receptor type 6

Receptor Organisms Mus musculus Mus musculus Mus musculus Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family NPY

Receptor Lengths 382 381 375 466 371

Receptor Ligands NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 5

Receptor Organisms Sus scrofa Sus scrofa Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family NPY

Receptor Lengths 383 382 446

Receptor Ligands NP07614 NP07556 NP07691 NP07697 NP07614 NP07556 NP07691 NP07697 NP07614 NP07556 NP07691 NP07697

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family NPY

Receptor Lengths 382 375 445

Receptor Ligands NP07557 NP07616 NP07693 NP07699 NP07557 NP07616 NP07693 NP07699 NP07557 NP07616 NP07693 NP07699

Family

NPY

Receptor_Lengths

382 446 381 375 466 371 383 445

Receptor_Ligands

NP07688 NP07694 NP07554 NP07611 NP07657 NP07690 NP07696 NP07614 NP07556 NP07691 NP07697 NP07557 NP07616 NP07693 NP07699