TPDB

3D PDB MODEL

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TPDB ID TPDB60793

Peptide_Name

CNP-29

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 29-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YKGGNKKGLSKGCFGLKLDRIGSMSGLGC

FASTA

>TPDB60793|Neuropeptide|length=29
YKGGNKKGLSKGCFGLKLDRIGSMSGLGC

Formula C128H216N38O37S3

Absent Amino Acids AEQHPTWV

Common Amino Acids G

Mass 2975.54

PI 10.20

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 8

Net Charge +5

Boman Index 2.55

Hydrophobicity -0.293

Aliphatic Index 67.24

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1615

Absorbance 280nm 54.28

Polar Residues 7

number

0

A

1

R

1

N

1

D

2

C

0

E

0

Q

8

G

0

H

1

I

4

L

5

K

1

M

1

F

0

P

3

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 8 H: 0 I: 1 L: 4 K: 5 M: 1 F: 1 P: 0 S: 3 T: 0 W: 0 Y: 1 V: 0

Length

29

Formula

C128H216N38O37S3

Mass

2975.54

PI

10.20

Net Charge

+5

Boman Index

2.55

Hydrophobicity

-0.293

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 2 Atrial natriuretic peptide receptor 3

Receptor Organisms Bos taurus Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Natriuretic peptide

Receptor Lengths 1047 537

Receptor Ligands NP06597 NP06605 NP06615 NP06433 NP06423 NP06582 NP06741 NP06597 NP06605 NP06615 NP06444 NP06455 NP06466 NP06477 NP06488 NP06499 NP06510 NP06585 NP06660 NP06677 NP06730 NP06762 NP06785

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 2 Atrial natriuretic peptide receptor 3

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Natriuretic peptide

Receptor Lengths 1047 536

Receptor Ligands NP06599 NP06607 NP06617 NP06439 NP06494 NP06483 NP06450 NP06461 NP06595 NP06745 NP06599 NP06607 NP06617 NP06472 NP06505 NP06516 NP06666 NP06683 NP06736 NP06768 NP06791

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Natriuretic peptide

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 2 Atrial natriuretic peptide receptor 3

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Natriuretic peptide

Receptor Lengths 1047 535

Receptor Ligands NP06601 NP06609 NP06619 NP06442 NP06453 NP06464 NP06475 NP06486 NP06497 NP06596 NP06747 NP06601 NP06609 NP06619 NP06508 NP06519 NP06669 NP06686 NP06739 NP06771 NP06794

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Natriuretic peptide

Family

Natriuretic peptide

Receptor_Lengths

1047 537 536 535

Receptor_Ligands

NP06597 NP06605 NP06615 NP06433 NP06423 NP06582 NP06741 NP06444 NP06455 NP06466 NP06477 NP06488 NP06499 NP06510 NP06585 NP06660 NP06677 NP06730 NP06762 NP06785 NP06599 NP06607 NP06617 NP06439 NP06494 NP06483 NP06450 NP06461 NP06595 NP06745 NP06472 NP06505 NP06516 NP06666 NP06683 NP06736 NP06768 NP06791 NP06601 NP06609 NP06619 NP06442 NP06453 NP06464 NP06475 NP06486 NP06497 NP06596 NP06747 NP06508 NP06519 NP06669 NP06686 NP06739 NP06771 NP06794