TPDB

3D PDB MODEL

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TPDB ID TPDB60768

Peptide_Name

Beta-endorphin

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ

FASTA

>TPDB60768|Neuropeptide|length=31
YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ

Formula C155H250N42O44S1

Absent Amino Acids RDCW

Common Amino Acids K

Mass 3438.01

PI 10.47

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +4

Boman Index 5.65

Hydrophobicity -0.519

Aliphatic Index 66.13

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 43.34

Polar Residues 10

number

2

A

0

R

2

N

0

D

0

C

1

E

2

Q

3

G

1

H

2

I

2

L

5

K

1

M

2

F

1

P

2

S

3

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 2 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 2 G: 3 H: 1 I: 2 L: 2 K: 5 M: 1 F: 2 P: 1 S: 2 T: 3 W: 0 Y: 1 V: 1

Length

31

Formula

C155H250N42O44S1

Mass

3438.01

PI

10.47

Net Charge

+4

Boman Index

5.65

Hydrophobicity

-0.519

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Mu-type opioid receptor Kappa-type opioid receptor

Receptor Organisms Bos taurus Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Opioid

Receptor Lengths 401 380

Receptor Ligands NP08047 NP07979 NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Camelus dromedarius

Family Opioid

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Kappa-type opioid receptor Mu-type opioid receptor

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Opioid

Receptor Lengths 380 398

Receptor Ligands NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987 NP07999 NP07987

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Neovison vison

Family Opioid

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Opioid

Family

Opioid

Receptor_Lengths

401 380 398

Receptor_Ligands

NP08047 NP07979 NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987