TPDB

3D PDB MODEL

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TPDB ID TPDB60738

Peptide_Name

Dynorphin A(1-8) Proenkephalin-B

Activity

Antidiabetic Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (Antidiabetic and Neuropeptide) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YGGFLRRI

FASTA

>TPDB60738|Antidiabetic;Neuropeptide|length=8
YGGFLRRI

Formula C46H72N14O10

Absent Amino Acids ANDCEQHKMPSTWV

Common Amino Acids RG

Mass 981.17

PI 11.16

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +2

Boman Index -1.30

Hydrophobicity 0.000

Aliphatic Index 97.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 151.86

Polar Residues 1

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

1

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

8

Formula

C46H72N14O10

Mass

981.17

PI

11.16

Net Charge

+2

Boman Index

-1.30

Hydrophobicity

0.000

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Kappa-type opioid receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Opioid

Receptor Lengths 380

Receptor Ligands NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Kappa-type opioid receptor

Receptor Organisms Cavia porcellus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family Opioid

Receptor Lengths 380

Receptor Ligands NP07972 NP08004 NP08010 NP08026 NP08033 NP08039 NP07981

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor Kappa-type opioid receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Opioid

Receptor Lengths 372 380

Receptor Ligands NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP07982

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Kappa-type opioid receptor

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Opioid

Receptor Lengths 380

Receptor Ligands NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Opioid

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor Kappa-type opioid receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Receptor Lengths 372 380

Receptor Ligands NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP07992

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Opioid

Family

Opioid

Receptor_Lengths

380 372

Receptor_Ligands

NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979 NP07972 NP08004 NP08010 NP08026 NP08033 NP08039 NP07981 NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07982 NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102