TPDB

3D PDB MODEL

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TPDB ID TPDB60586

Peptide_Name

Melanotropin gamma

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YVMGHFRWDRF

FASTA

>TPDB60586|Neuropeptide|length=11
YVMGHFRWDRF

Formula C72H96N20O15S1

Absent Amino Acids ANCEQILKPST

Common Amino Acids RF

Mass 1513.74

PI 9.87

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +1

Boman Index -1.39

Hydrophobicity -0.600

Aliphatic Index 26.36

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 461.77

Polar Residues 1

number

0

A

2

R

0

N

1

D

0

C

0

E

0

Q

1

G

1

H

0

I

0

L

0

K

1

M

2

F

0

P

0

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 1 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1

Length

11

Formula

C72H96N20O15S1

Mass

1513.74

PI

9.87

Net Charge

+1

Boman Index

-1.39

Hydrophobicity

-0.600

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Bos taurus Bos taurus Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family POMC

Receptor Lengths 332 325 317

Receptor Ligands NP08979 NP09082 NP09107 NP09134 NP08979 NP09082 NP09107 NP09134 NP08979 NP09082 NP09107 NP09134

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family POMC

Receptor Lengths 323 332 325 317

Receptor Ligands NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocyte-stimulating hormone receptor

Receptor Organisms Macaca nemestrina

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca nemestrina

Family POMC

Receptor Lengths 317

Receptor Ligands NP09138 NP08985 NP09088 NP09113

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Mus musculus Mus musculus Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family POMC

Receptor Lengths 323 332 325 315

Receptor Ligands NP08974 NP08986 NP09089 NP09114 NP09139 NP08974 NP08986 NP09089 NP09114 NP09139 NP08974 NP08986 NP09089 NP09114 NP09139 NP08974 NP08986 NP09089 NP09114 NP09139

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 4 Melanocyte-stimulating hormone receptor Melanocortin receptor 5

Receptor Organisms Sus scrofa Sus scrofa Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family POMC

Receptor Lengths 332 320 294

Receptor Ligands NP09141 NP08990 NP09093 NP09118 NP09141 NP08990 NP09093 NP09118 NP09141 NP08990 NP09093 NP09118

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family POMC

Receptor Lengths 323 332 325

Receptor Ligands NP08992 NP09095 NP09119 NP09142 NP08102 NP08992 NP09095 NP09119 NP09142 NP08102 NP08992 NP09095 NP09119 NP09142 NP08102

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Ovis aries Ovis aries

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family POMC

Receptor Lengths 325 317

Receptor Ligands NP09143 NP08993 NP09096 NP09120 NP09143 NP08993 NP09096 NP09120

Family

POMC

Receptor_Lengths

332 325 317 323 315 320 294

Receptor_Ligands

NP08979 NP09082 NP09107 NP09134 NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035 NP09138 NP08985 NP09088 NP09113 NP08974 NP08986 NP09089 NP09114 NP09139 NP09141 NP08990 NP09093 NP09118 NP08992 NP09095 NP09119 NP09142 NP08102 NP09143 NP08993 NP09096 NP09120