TPDB

3D PDB MODEL

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TPDB ID TPDB60523

Peptide_Name

Neuromedin U Neuromedin-U-23

Activity

Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

B3Pred BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.

Sequence

YKVNEYQGPVAPSGGFFLFRPRN

FASTA

>TPDB60523|Blood-Brain Barrier;Neuropeptide|length=23
YKVNEYQGPVAPSGGFFLFRPRN

Formula C124H179N33O32

Absent Amino Acids DCHIMTW

Common Amino Acids GFP

Mass 2643.99

PI 10.08

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +2

Boman Index 1.70

Hydrophobicity -0.604

Aliphatic Index 46.52

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 112.71

Polar Residues 6

number

1

A

2

R

2

N

0

D

0

C

1

E

1

Q

3

G

0

H

0

I

1

L

1

K

0

M

3

F

3

P

1

S

0

T

0

W

2

Y

2

V

Amino Acid Distribution

A: 1 R: 2 N: 2 D: 0 C: 0 E: 1 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 1 M: 0 F: 3 P: 3 S: 1 T: 0 W: 0 Y: 2 V: 2

Length

23

Formula

C124H179N33O32

Mass

2643.99

PI

10.08

Net Charge

+2

Boman Index

1.70

Hydrophobicity

-0.604

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0112 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 83%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 17%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00131 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuromedin-U receptor 1 Neuromedin-U receptor 2

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Neuromedins

Receptor Lengths 425 395

Receptor Ligands NP06825 NP06831 NP06814 NP06817 NP06825 NP06831 NP06814 NP06817

Family

Neuromedins

In_Vivo_Mode_of_Delivery

Intravenous

Receptor_Lengths

425 395

Receptor_Ligands

NP06825 NP06831 NP06814 NP06817