TPDB

3D PDB MODEL

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TPDB ID TPDB60497

Peptide_Name

Met-enkephalin-Arg-Gly-Leu Proenkephalin-A

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YGGFMRGL

FASTA

>TPDB60497|Neuropeptide|length=8
YGGFMRGL

Formula C41H61N11O10S1

Absent Amino Acids ANDCEQHIKPSTWV

Common Amino Acids G

Mass 900.06

PI 9.88

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index -2.02

Hydrophobicity 0.187

Aliphatic Index 48.75

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 165.54

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

3

G

0

H

0

I

1

L

0

K

1

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

8

Formula

C41H61N11O10S1

Mass

900.06

PI

9.88

Net Charge

+1

Boman Index

-2.02

Hydrophobicity

0.187

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Opioid

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family Opioid

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Opioid

Receptor Lengths 372

Receptor Ligands NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mesocricetus auratus

Family Opioid

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Receptor Lengths 372

Receptor Ligands NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Hippocampus

Family Opioid

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Family

Opioid

Receptor_Lengths

372

Receptor_Ligands

NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102