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Peptide record

TPDB60367

Urocortin II Urocortin-2 Blood-Brain Barrier Neuropeptide standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB60367
Urocortin II Urocortin-2
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
BBPpredict Peptipedia
standard
No
A 38-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.
Sequence
VILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHV
Physicochemical Analysis
C187H319N55O51
CMFW
AL
4153.93
10.41
5
2
22
+2
3.86
0.524
154.21
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
35.87
8
Residue Composition
number
7
A
3
R
2
N
1
D
0
C
1
E
3
Q
1
G
1
H
4
I
7
L
1
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 7 R: 3 N: 2 D: 1 C: 0 E: 1 Q: 3 G: 1 H: 1 I: 4 L: 7 K: 1 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
38
C187H319N55O51
4153.93
10.41
+2
3.86
0.524
Linear
Similarity
Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val
Evidence Records 11 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0863 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

rat
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
8.03 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

rat
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.02021 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

rat
in situ brain perfusion
non saturable
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
5%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

rat
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
95%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

rat
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.0199 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (parenchyma/serum)

Source & Reference

NA
B3Pdb

Other

rat
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
0.00103 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (capillary/serum)

Source & Reference

NA
B3Pdb

Other

rat
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
0.0237 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (brain/serum)

Source & Reference

NA
B3Pdb

Other

rat
Direct iodination
Evidence 9 Activity

Activity

Blood-Brain Barrier
-0.4

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

rat
Direct iodination
Evidence 10 Activity

Activity

Blood-Brain Barrier
0.0005905 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

rat
Intravenous
non saturable
Direct iodination
Evidence 11 Activity

Activity

Neuropeptide

Target

Corticotropin-releasing factor receptor 2
Mus musculus

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Sauvagine/corticotropin-releasing factor/urotensin I
411
NP09857 NP09914 NP09919 NP09923
Additional Detail Fields 4 fields
Sauvagine/corticotropin-releasing factor/urotensin I
in situ brain perfusion Intravenous
411
NP09857 NP09914 NP09919 NP09923