TPDB

3D PDB MODEL

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TPDB ID TPDB59946

Peptide_Name

Corticotropin

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEF

FASTA

>TPDB59946|Neuropeptide|length=39
SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEF

Formula C207H309N57O57S1

Absent Amino Acids CIT

Common Amino Acids EKP

Mass 4540.14

PI 9.82

Basic Residues 8

Acidic Residues 5

Hydrophobic Residues 14

Net Charge +2

Boman Index 11.67

Hydrophobicity -0.979

Aliphatic Index 40.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 8480

Absorbance 280nm 186.78

Polar Residues 7

number

3

A

3

R

1

N

1

D

0

C

4

E

1

Q

3

G

1

H

0

I

1

L

4

K

1

M

3

F

4

P

3

S

0

T

1

W

2

Y

3

V

Amino Acid Distribution

A: 3 R: 3 N: 1 D: 1 C: 0 E: 4 Q: 1 G: 3 H: 1 I: 0 L: 1 K: 4 M: 1 F: 3 P: 4 S: 3 T: 0 W: 1 Y: 2 V: 3

Length

39

Formula

C207H309N57O57S1

Mass

4540.14

PI

9.82

Net Charge

+2

Boman Index

11.67

Hydrophobicity

-0.979

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Adrenocorticotropic hormone receptor Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Bos taurus Bos taurus Bos taurus Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family POMC

Receptor Lengths 297 332 325 317

Receptor Ligands NP08979 NP08979 NP09082 NP09107 NP09134 NP08979 NP09082 NP09107 NP09134 NP08979 NP09082 NP09107 NP09134

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Adrenocorticotropic hormone receptor Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Ovis aries Ovis aries Ovis aries

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family POMC

Receptor Lengths 295 325 317

Receptor Ligands NP08993 NP09143 NP08993 NP09096 NP09120 NP09143 NP08993 NP09096 NP09120

Family

POMC

Receptor_Lengths

297 332 325 317 295

Receptor_Ligands

NP08979 NP09082 NP09107 NP09134 NP08993 NP09143 NP09096 NP09120