TPDB

3D PDB MODEL

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TPDB ID TPDB59536

Peptide_Name

Atriopeptin-2

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SSCFGGRMDRIGAQSGLGCNSFR

FASTA

>TPDB59536|Neuropeptide|length=23
SSCFGGRMDRIGAQSGLGCNSFR

Formula C97H156N34O32S3

Absent Amino Acids EHKPTWYV

Common Amino Acids G

Mass 2406.69

PI 9.19

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +2

Boman Index 1.22

Hydrophobicity -0.287

Aliphatic Index 38.26

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 5.19

Polar Residues 8

number

1

A

3

R

1

N

1

D

2

C

0

E

1

Q

5

G

0

H

1

I

1

L

0

K

1

M

2

F

0

P

4

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 3 N: 1 D: 1 C: 2 E: 0 Q: 1 G: 5 H: 0 I: 1 L: 1 K: 0 M: 1 F: 2 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 0

Length

23

Formula

C97H156N34O32S3

Mass

2406.69

PI

9.19

Net Charge

+2

Boman Index

1.22

Hydrophobicity

-0.287

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 3

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Natriuretic peptide

Receptor Lengths 537

Receptor Ligands NP06433 NP06423 NP06582 NP06741 NP06597 NP06605 NP06615 NP06444 NP06455 NP06466 NP06477 NP06488 NP06499 NP06510 NP06585 NP06660 NP06677 NP06730 NP06762 NP06785

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Natriuretic peptide

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Felis catus

Family Natriuretic peptide

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Equus caballus

Family Natriuretic peptide

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 1 Atrial natriuretic peptide receptor 3

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Natriuretic peptide

Receptor Lengths 1061 541

Receptor Ligands NP06438 NP06449 NP06460 NP06471 NP06482 NP06493 NP06504 NP06515 NP06522 NP06523 NP06524 NP06525 NP06526 NP06527 NP06528 NP06529 NP06530 NP06531 NP06532 NP06533 NP06534 NP06535 NP06588 NP06591 NP06665 NP06682 NP06735 NP06744 NP06750 NP06759 NP06767 NP06790 NP06438 NP06449 NP06460 NP06471 NP06482 NP06493 NP06504 NP06515 NP06522 NP06523 NP06524 NP06525 NP06526 NP06527 NP06528 NP06529 NP06530 NP06531 NP06532 NP06533 NP06534 NP06535 NP06588 NP06591 NP06665 NP06682 NP06735 NP06744 NP06750 NP06759 NP06767 NP06790 NP06598 NP06606 NP06616

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Natriuretic peptide

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Natriuretic peptide

Family

Natriuretic peptide

Receptor_Lengths

537 1061 541

Receptor_Ligands

NP06433 NP06423 NP06582 NP06741 NP06597 NP06605 NP06615 NP06444 NP06455 NP06466 NP06477 NP06488 NP06499 NP06510 NP06585 NP06660 NP06677 NP06730 NP06762 NP06785 NP06438 NP06449 NP06460 NP06471 NP06482 NP06493 NP06504 NP06515 NP06522 NP06523 NP06524 NP06525 NP06526 NP06527 NP06528 NP06529 NP06530 NP06531 NP06532 NP06533 NP06534 NP06535 NP06588 NP06591 NP06665 NP06682 NP06735 NP06744 NP06750 NP06759 NP06767 NP06790 NP06598 NP06606 NP06616