TPDB

3D PDB MODEL

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TPDB ID TPDB58520

Peptide_Name

Calcitonin gene-related peptide 1

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 37-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

FASTA

>TPDB58520|Neuropeptide|length=37
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

Formula C162H263N49O53S2

Absent Amino Acids QIMWY

Common Amino Acids V

Mass 3809.29

PI 8.30

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +1

Boman Index 5.07

Hydrophobicity 0.151

Aliphatic Index 78.92

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.28

Polar Residues 13

number

3

A

2

R

3

N

1

D

2

C

1

E

0

Q

4

G

1

H

0

I

3

L

1

K

0

M

2

F

1

P

4

S

4

T

0

W

0

Y

5

V

Amino Acid Distribution

A: 3 R: 2 N: 3 D: 1 C: 2 E: 1 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 1 M: 0 F: 2 P: 1 S: 4 T: 4 W: 0 Y: 0 V: 5

Length

37

Formula

C162H263N49O53S2

Mass

3809.29

PI

8.30

Net Charge

+1

Boman Index

5.07

Hydrophobicity

0.151

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Calcitonin gene-related peptide type 1 receptor Receptor activity-modifying protein 2 Receptor activity-modifying protein 3 Receptor activity-modifying protein 1

Receptor Organisms Mus musculus Mus musculus Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Calcitonin

Receptor Lengths 463 189 147 148

Receptor Ligands NP00053 NP00057 NP00048 NP00062 NP01796 NP01800 NP00053 NP00048 NP01796 NP01800 NP00053 NP00048 NP01796 NP01800 NP01796 NP01800

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Calcitonin gene-related peptide type 1 receptor Receptor activity-modifying protein 2 Receptor activity-modifying protein 3 Receptor activity-modifying protein 1

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Calcitonin

Receptor Lengths 464 182 147 148

Receptor Ligands NP00054 NP00058 NP00050 NP00064 NP01797 NP01801 NP00054 NP00050 NP01797 NP01801 NP00054 NP00050 NP01797 NP01801 NP01797 NP01801

Family

Calcitonin

Receptor_Lengths

463 189 147 148 464 182

Receptor_Ligands

NP00053 NP00057 NP00048 NP00062 NP01796 NP01800 NP00054 NP00058 NP00050 NP00064 NP01797 NP01801