TPDB

3D PDB MODEL

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TPDB ID TPDB57831

Peptide_Name

Progonadoliberin-1

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 69-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

QHWSYGLRPGGKRNTEHLVDSFQEMGKEEDQMAEPQNFECTVHWPRSPLRDLRGALERLIEEEAGQKKM

FASTA

>TPDB57831|Neuropeptide|length=69
QHWSYGLRPGGKRNTEHLVDSFQEMGKEEDQMAEPQNFECTVHWPRSPLRDLRGALERLIEEEAGQKKM

Formula C350H544N106O109S4

Absent Amino Acids

Common Amino Acids E

Mass 8109.05

PI 5.45

Basic Residues 13

Acidic Residues 13

Hydrophobic Residues 20

Net Charge -3

Boman Index 29.99

Hydrophobicity -1.203

Aliphatic Index 52.32

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 12490

Absorbance 280nm 154.03

Polar Residues 14

number

3

A

6

R

2

N

3

D

1

C

10

E

5

Q

6

G

3

H

1

I

6

L

4

K

3

M

2

F

4

P

3

S

2

T

2

W

1

Y

2

V

Amino Acid Distribution

A: 3 R: 6 N: 2 D: 3 C: 1 E: 10 Q: 5 G: 6 H: 3 I: 1 L: 6 K: 4 M: 3 F: 2 P: 4 S: 3 T: 2 W: 2 Y: 1 V: 2

Length

69

Formula

C350H544N106O109S4

Mass

8109.05

PI

5.45

Net Charge

-3

Boman Index

29.99

Hydrophobicity

-1.203

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Gonadotropin-releasing hormone receptor

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family GnRH

Receptor Lengths 327

Receptor Ligands NP04625 NP04579 NP04643 NP04681 NP04682 NP04649

Family

GnRH

Receptor_Lengths

327

Receptor_Ligands

NP04625 NP04579 NP04643 NP04681 NP04682 NP04649