TPDB

3D PDB MODEL

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TPDB ID TPDB57825

Peptide_Name

Progonadoliberin-1

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 69-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

QHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI

FASTA

>TPDB57825|Neuropeptide|length=69
QHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI

Formula C344H551N101O110S1

Absent Amino Acids M

Common Amino Acids E

Mass 7893.83

PI 5.53

Basic Residues 12

Acidic Residues 12

Hydrophobic Residues 20

Net Charge -2

Boman Index 28.36

Hydrophobicity -0.925

Aliphatic Index 74.93

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 88.55

Polar Residues 17

number

3

A

5

R

1

N

3

D

1

C

9

E

6

Q

6

G

2

H

4

I

7

L

5

K

0

M

2

F

3

P

4

S

4

T

1

W

1

Y

2

V

Amino Acid Distribution

A: 3 R: 5 N: 1 D: 3 C: 1 E: 9 Q: 6 G: 6 H: 2 I: 4 L: 7 K: 5 M: 0 F: 2 P: 3 S: 4 T: 4 W: 1 Y: 1 V: 2

Length

69

Formula

C344H551N101O110S1

Mass

7893.83

PI

5.53

Net Charge

-2

Boman Index

28.36

Hydrophobicity

-0.925

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Gonadotropin-releasing hormone receptor

Receptor Organisms Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family GnRH

Receptor Lengths 328

Receptor Ligands NP04507 NP04569 NP04634 NP04522 NP04592 NP04653

Family

GnRH

Receptor_Lengths

328

Receptor_Ligands

NP04507 NP04569 NP04634 NP04522 NP04592 NP04653