TPDB

3D PDB MODEL

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TPDB ID TPDB55251

Peptide_Name

Cholecystokinin-12

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

ISDRDYMGWMDF

FASTA

>TPDB55251|Neuropeptide|length=12
ISDRDYMGWMDF

Formula C68H94N16O21S2

Absent Amino Acids ANCEQHLKPTV

Common Amino Acids D

Mass 1535.71

PI 3.59

Basic Residues 1

Acidic Residues 3

Hydrophobic Residues 6

Net Charge -2

Boman Index -0.05

Hydrophobicity -0.608

Aliphatic Index 32.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 455.16

Polar Residues 2

number

0

A

1

R

0

N

3

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

2

M

1

F

0

P

1

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 3 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 2 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0

Length

12

Formula

C68H94N16O21S2

Mass

1535.71

PI

3.59

Net Charge

-2

Boman Index

-0.05

Hydrophobicity

-0.608

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Gastrin/cholecystokinin type B receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Gastrin/cholecystokinin

Receptor Lengths 454

Receptor Ligands NP03854 NP03893 NP03901 NP03907 NP03913 NP03923 NP03930 NP03935 NP03944 NP03951 NP03964 NP03801 NP04005

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Canis lupus familiaris Canis lupus familiaris

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Gastrin/cholecystokinin

Receptor Lengths 428 453

Receptor Ligands NP03936 NP03945 NP03924 NP03914 NP03908 NP03902 NP03894 NP03965 NP03952 NP03931 NP03802 NP04006 NP03936 NP03945 NP03924 NP03914 NP03908 NP03902 NP03894 NP03965 NP03952 NP03931

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Gastrin/cholecystokinin

Receptor Lengths 428 447

Receptor Ligands NP03809 NP03858 NP03896 NP03903 NP03909 NP03915 NP03925 NP03932 NP03937 NP03946 NP03954 NP03968 NP04013 NP04026 NP04029 NP04030 NP04031 NP03809 NP03858 NP03896 NP03903 NP03909 NP03915 NP03925 NP03932 NP03937 NP03946 NP03954 NP03968 NP04013 NP04026 NP04029 NP04030 NP04031

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca fascicularis

Family Gastrin/cholecystokinin

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Gastrin/cholecystokinin

Receptor Lengths 436 453

Receptor Ligands NP03942 NP03862 NP03898 NP03918 NP03971 NP03871 NP03872 NP03873 NP03874 NP03875 NP03876 NP03877 NP03878 NP03879 NP03880 NP03881 NP03882 NP03883 NP03884 NP03885 NP03886 NP03942 NP03862 NP03898 NP03918 NP03971 NP03811 NP04015 NP04032 NP03871 NP03872 NP03873 NP03874 NP03875 NP03876 NP03877 NP03878 NP03879 NP03880 NP03881 NP03882 NP03883 NP03884 NP03885 NP03886

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Gastrin/cholecystokinin type B receptor

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Gastrin/cholecystokinin

Receptor Lengths 452

Receptor Ligands NP03890 NP03943 NP03864 NP03940 NP03948 NP03927 NP03919 NP03911 NP03905 NP03899 NP03973 NP03957 NP03934 NP03812 NP04016

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Gastrin/cholecystokinin

Receptor Lengths 444 452

Receptor Ligands NP03865 NP03900 NP03906 NP03920 NP03928 NP03974 NP03887 NP03865 NP03900 NP03906 NP03920 NP03928 NP03974 NP03813 NP04017 NP03887

Family

Gastrin/cholecystokinin

Receptor_Lengths

454 428 453 447 436 452 444

Receptor_Ligands

NP03854 NP03893 NP03901 NP03907 NP03913 NP03923 NP03930 NP03935 NP03944 NP03951 NP03964 NP03801 NP04005 NP03936 NP03945 NP03924 NP03914 NP03908 NP03902 NP03894 NP03965 NP03952 NP03931 NP03802 NP04006 NP03809 NP03858 NP03896 NP03903 NP03909 NP03915 NP03925 NP03932 NP03937 NP03946 NP03954 NP03968 NP04013 NP04026 NP04029 NP04030 NP04031 NP03942 NP03862 NP03898 NP03918 NP03971 NP03871 NP03872 NP03873 NP03874 NP03875 NP03876 NP03877 NP03878 NP03879 NP03880 NP03881 NP03882 NP03883 NP03884 NP03885 NP03886 NP03811 NP04015 NP04032 NP03890 NP03943 NP03864 NP03940 NP03948 NP03927 NP03919 NP03911 NP03905 NP03899 NP03973 NP03957 NP03934 NP03812 NP04016 NP03865 NP03900 NP03906 NP03920 NP03928 NP03974 NP03887 NP03813 NP04017