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Peptide record

TPDB55165

Peptide YY (3-36) Blood-Brain Barrier Neuropeptide standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB55165
Peptide YY (3-36)
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
BBPpredict Peptipedia
standard
No
A 34-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.
Sequence
IKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY
Physicochemical Analysis
C180H278N52O55
CMFW
RELY
4050.50
7.63
6
5
13
+0
10.93
-1.074
74.71
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5960
147.14
10
Residue Composition
number
3
A
4
R
2
N
1
D
0
C
4
E
1
Q
1
G
1
H
1
I
4
L
1
K
0
M
0
F
3
P
2
S
1
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 3 R: 4 N: 2 D: 1 C: 0 E: 4 Q: 1 G: 1 H: 1 I: 1 L: 4 K: 1 M: 0 F: 0 P: 3 S: 2 T: 1 W: 0 Y: 4 V: 1
Chemical Descriptors
34
C180H278N52O55
4050.50
7.63
+0
10.93
-1.074
Linear
Similarity
Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr
Evidence Records 11 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0183 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
37.8 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
26.56 %/g

Assay & Model

Efflux study ICU
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.00234 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
non saturable
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
69%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.0011 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (capillary/serum)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
0.00247 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (parenchyma/serum)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
31%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable
Direct iodination
Evidence 9 Activity

Activity

Blood-Brain Barrier
0.00049 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Evidence 10 Activity

Activity

Blood-Brain Barrier
0.012 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Evidence 11 Activity

Activity

Blood-Brain Barrier
0.176 %/g

Assay & Model

Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Additional Detail Fields 1 fields
in situ brain perfusion Intravenous