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Peptide record

TPDB54587

Des-octanoyl ghrelin Ghrelin mouse Des-octanoyl G Blood-Brain Barrier Neuropeptide standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB54587
Des-octanoyl ghrelin Ghrelin mouse Des-octanoyl G
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
B3Pred BBPpredict Peptipedia
standard
No
A 28-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
GSSFLSPEHQKAQQRKESKKPPAKLQPR
Physicochemical Analysis
C139H231N45O41
NDCIMTWYV
K
3188.64
11.08
8
2
5
+5
13.63
-1.739
35.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
8
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
2
E
4
Q
1
G
1
H
0
I
2
L
5
K
0
M
1
F
4
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 2 Q: 4 G: 1 H: 1 I: 0 L: 2 K: 5 M: 0 F: 1 P: 4 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C139H231N45O41
3188.64
11.08
+5
13.63
-1.739
Linear
Similarity
Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000573 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
non saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.011 ml/g

Assay & Model

Origin/Source
Initial distribution vaolume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
non saturable
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.02 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
-1.95

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.0002606 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.002265 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
Direct iodination
Evidence 7 Activity

Activity

Neuropeptide

Target

Growth hormone secretagogue receptor type 1
Mus musculus

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Motilin
364
NP05491 NP05529
Evidence 8 Activity

Activity

Neuropeptide

Target

Growth hormone secretagogue receptor type 1
Rattus norvegicus

Source & Reference

NA
NeuroPepV2

Other

Rattus norvegicus
Motilin
364
NP05494 NP05532 NP05533
Additional Detail Fields 4 fields
Motilin
in situ brain perfusion Intravenous
364
NP05491 NP05529 NP05494 NP05532 NP05533